Publications Since 2020

Dr. Wang is an author or co-author of over 340 research articles. For a full list of his publications, see his full CV.

2024

Dual-Performing Vinyltetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins

Xiang Meng, Chao Che, Yue Dong, Qiangqiang Liu, Wei Wang

ACS Chem Bio. 2024

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C–H Bonds via H/D Exchange with D2O

Xiang Meng, Chao Che, Yue Dong, Qiangqiang Liu, Wei Wang

Org. Lett. 2024, 26,41, 8961–8966

Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Mengyang Chang, Feng Gao, Giri Gnawali, Hang Xu, Yue Dong, Xiang Meng, Wenpan Li, Zhiren Wang, Byrdie Lopez, Jennifer S Carew, Steffan T Nawrocki, Jianqin Lu, Qing-Yu Zhang, Wei Wang

J Med Chem. 2024, 67, 9, 7301–7311

Elimination of Senescent Cells Abstract Image.gif

Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation

Mengyang Chang, Yue Dong, Hang Xu, Alexis B. Cruickshank-Taylor, Jacob S. Kozora, Baran Behpour, Prof. Dr. Wei Wang

Angew. Chem. Int. Ed. 2024, 63, 9

Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D O

2

Xiang Meng, Yue Dong, Qiangqiang Liu and Wei Wang

Chem. Commun, 2024, 60, 296-299

2023

Control of tetrazine bioorthogonal reactivity by naphthotube and phenyltetrazine host-guest pairs

Kaiyan Lou, Wanjin Xing, Xiang Meng, Mengyang Chang, Wei Wang

Chem, 2023, 9,10, 2727-2730

Site-Selective Modification of Secondary Amine Moieties on Native Peptides, Proteins, and Natural Products with Ynones

Feng Gao, Mengyang Chang, Xiang Meng, Hang Xu, Giri Gnawali, Yue Dong, Byrdie Lopez, Wei Wang

Bioconjugate Chem. 2023, 34, 9, 1553–1562

Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives

Yue Dong, Xiang Meng, Giri Gnawali, Mengyang Chang, and Wei Wang

Org. Lett. 2023, 25, 25, 4745–4749

2022

Design of Photoredox-Catalyzed Giese-Type Reaction for the Synthesis of Chiral Quaternary α-Aryl Amino Acid Derivatives via Clayden Rearrangement

Peng Ji, Jing Chen, Xiang Meng, Feng Gao, Yue Dong, Hang Xu, Wei Wang

J. Org. Chem. 2022, 87, 21, 14706–14714

Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization

Peng Ji, Cassondra Davies, Feng Gao, Jing Chen, Xiang Meng, Kendall Hou, Shuming Chen, Wei Wang

Nature Communications. 2022, 13; 4565

Synthesis of C-1 Deuterated 3-Formylindoles by Organophotoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid

Yue Dong, Xiangmin Li, Peng Ji, Feng Gao, Xiang Meng,

Wei Wang

Org. Lett. 2022, 24:28, 5034-5039

Synthesis of 𝛼-Aryl Primary Amides from 𝛼-Silyl Nitriles and Aryl Sulfides through [3,3]-Sigmatropic Rearrangement

Fan Luo, Hui Zhou, Xiao-Bei Chen, Xue-Jun Liu, Xiao-Dong Chen, Peng-Fei Qian, Xin-Ping Wu, Wei Wang, Shi-Lei Zhang

Org. Lett. 2022, 24:8, 1700-1705

Screen Shot 2022-10-29 at 10.40.36 PM.png

Designing Efficient Cascade Reactions in Drug Discovery

Chenguang Yu, He Huang, Chunquan Sheng, Wei Wang

Green Chemistry in Drug Discovery. 2022, 213-235

Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development

Ian Henderson, Fanxun Zheng, Nazmul Bhuiyan, Dan Luo, Maria Martinez, Jane Smoake, Fangchao Bi, Chamani Perera, David Johnson, Thomas Prisinzano, Wei Wang, George Uhl

Biochemical pharmacology. 2022, 195, 114868

Screen Shot 2022-10-29 at 11.34.23 PM.png

2021

A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

Junwei Chen, Na Wang, Hongjuan Tong, Chao Song, Huijuan Ma, Yajun Zhang, Feng Gao, Huan Xu, Wei Wang, Kaiyan Lou

Chinese Chemical Letters. 2021, 32:12, 3876-3881

Screen Shot 2022-10-29 at 11.48.45 PM.png

Aminocatalytic stereoselective synthesis of (E)-𝛼-naphthyl enals via cross-coupling reaction of 1-bromo-2-napthols with enals

Xixi Song, Fangchen Song, Xiang Meng, Peng Ji, Wei Wang

Green Synthesis and Catalysis. 2021, 2:4, 377-380

Screen Shot 2022-10-29 at 11.58.04 PM.png

Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis acid Cascade Cocatalysis

Chenguang Yu, Peng Ji, Yueteng Zheng, Xiang Meng, Wei Wang

Org. Lett. 2021, 23:19, 7656-7660

Organophotocatalytic dearomatization of insoles, pyrrole and bento (thio) furans via a Giese-type transformation

Yueteng Zhang, Peng Ji, Feng Gao, Yue Dong, He Huang, Changqing Wang, Ziyuan Zhou, Wei Wang

Communications Chemistry. 2021, 4:1, 1-13

Screen Shot 2022-10-30 at 12.28.37 AM.png

Organophotocatalyzed E and Z stereoselective Csp3-Csp2 bond forming cross coupling reactions of carboxylic acids with β-aryl-vinyl halides

He Huang, Yueteng Zheng, Peng Ji, Patrick Mariano, Wei Wang

Green Synthesis and Catalysis. 2021, 2:1, 27-31

Screen Shot 2022-10-30 at 12.39.35 AM.png

Photoredox Asymmetric Nucleophilic Dearomatization of Indoles with Neutral Radicals

Yueteng Zhang, Peng Ji, Feng Gao, He Huang, Fanxun Zeng, Wei Wang

ACS Catal. 2021, 11:2, 998-1007

Screen Shot 2022-10-30 at 12.57.15 AM.png

Facile Synthesis of 2H-Benzo[H]Chromenes via an Arylamine-Catalyzed Mannich Cyclization Cascade Reaction

Yueteng Zhang, Peng Ji, Xiang Meng, Feng Gao, Fanxun Zeng, Wei Wang

Molecules. 2021, 26:12, 3617

2020

Organophotoredox-Catalyzed Formation of Alkyl-Aryl and- Alkyl C-S/Se Bonds from Coupling of Redox-Active Esters with Thio/Selenosulfonates

Yue Dong, Peng Ji, Yueteng Zhang, Changqing Wang, Xiang Meng, Wei Wang

Org. Lett. 2020, 22:24, 9562-9567

Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

Yue Dong, Renshuai Liu, Wei Wang

Green Synthesis and Catalysis. 2020, 1:2, 83-85

An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties

Niloufar Mollasalehi, Liberty Francois-Moutal, David Scott, Judith Tello, Haley Williams, Brendan Mahoney, Jacob Carlson, Yue Dong, Xingli Li, Victor Miranda, Vijay Gokhale, Wei Wang, Sami Barmada, May Khanna

ACS Chem. Biol. 2020, 15:11, 2854-2859

Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused Oxepanes

Xiaobei Chen, Yuanrui Jiang, Huihui Geng, Xingyu Liu, Yizhuo Huang, Jingwei Lu, Chenjing Gao, Shilei Zhang, Jiang Zhang, Wei Wang

Adv. Synth. Cal. 2020, 362:13, 2620-2625

Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis

Jing Chen, Yiwei Fu, Yang Yu, Jian-Rong Wang, Yue-Wei Guo, Hao Li, Wei Wang

Org. Lett. 2020, 22:15, 6061-6066

Screen Shot 2022-10-30 at 2.44.52 PM.png

One-pot synthesis of salicylaldehyde containing biaryl frameworks via an aminocatalytic Diels-Alder-retro-Diels-Alder cascade reaction of ynals with 2-pyrones

Xixi Song, Yueteng Zhang, Peng Ji, Fanxun Zeng, Fangchao Bi, Wei Wang

Green Synthesis and Catalysis. 2020, 1:1, 66-69

Publications Since 2020

2024

Dual-Performing Vinyltetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C–H Bonds via H/D Exchange with D2O

Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Senolysis Enabled by Senescent Cell‐Sensitive Bioorthogonal Tetrazine Ligation

Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D O

2

2023

Control of tetrazine bioorthogonal reactivity by naphthotube and phenyltetrazine host-guest pairs

Site-Selective Modification of Secondary Amine Moieties on Native Peptides, Proteins, and Natural Products with Ynones

Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives

2022

Design of Photoredox-Catalyzed Giese-Type Reaction for the Synthesis of Chiral Quaternary α-Aryl Amino Acid Derivatives via Clayden Rearrangement

Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization

Synthesis of C-1 Deuterated 3-Formylindoles by Organophotoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid

Synthesis of 𝛼-Aryl Primary Amides from 𝛼-Silyl Nitriles and Aryl Sulfides through [3,3]-Sigmatropic Rearrangement

Designing Efficient Cascade Reactions in Drug Discovery

Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development

A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

Aminocatalytic stereoselective synthesis of (E)-𝛼-naphthyl enals via cross-coupling reaction of 1-bromo-2-napthols with enals

Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis acid Cascade Cocatalysis

Organophotocatalytic dearomatization of insoles, pyrrole and bento (thio) furans via a Giese-type transformation

Organophotocatalyzed E and Z stereoselective Csp3-Csp2 bond forming cross coupling reactions of carboxylic acids with β-aryl-vinyl halides

Photoredox Asymmetric Nucleophilic Dearomatization of Indoles with Neutral Radicals

Facile Synthesis of 2H-Benzo[H]Chromenes via an Arylamine-Catalyzed Mannich Cyclization Cascade Reaction

Organophotoredox-Catalyzed Formation of Alkyl-Aryl and- Alkyl C-S/Se Bonds from Coupling of Redox-Active Esters with Thio/Selenosulfonates

Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties

Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused Oxepanes

Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis

One-pot synthesis of salicylaldehyde containing biaryl frameworks via an aminocatalytic Diels-Alder-retro-Diels-Alder cascade reaction of ynals with 2-pyrones

Synthesis of Enantioenriched 𝛼-Deuterated 𝛼-Amino Acids Enabled by an Organophotocatalytic Radical Approach

Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach

Copper Promoted Aerobic Oxidative C(sp3)-C(sp3) Bond Cleavage of N-(2-(Pyridine-2-yl)-ethyl)anilines

Direct, stereoselective thioglycosylation enabled by an organophotoredox radical strategy

Publications Since 2020

2024

Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D O

2

2023

Control of tetrazine bioorthogonal reactivity by naphthotube and phenyltetrazine host-guest pairs

​Site-Selective Modification of Secondary Amine Moieties on Native Peptides, Proteins, and Natural Products with Ynones

Photoredox Catalytic Installation of an Alkyl/Aryl Side Chain and Deuterium into (S)-Methyleneoxazolidinone: Synthesis of Enantioenriched α-Deuterated α-Amino Acid Derivatives

2022

Site-Selective Modification of Secondary Amine Moieties on Native Peptides, Proteins, and Natural Products with Ynones