top of page
This site was designed with the
.com
website builder. Create your website today.Start Now

2022

Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization

Peng Ji, Cassondra Davies, Feng Gao, Jing Chen, Xiang Meng, Kendall Hou, Shuming Chen, Wei Wang  

Nature Communications. 2022, 13; 4565 

Synthesis of C-1 Deuterated 3-Formylindoles by Organophotoredox Catalyzed Direct Formylation of Indoles with Deuterated Glyoxylic Acid 

Yue Dong, Xiangmin Li, Peng Ji, Feng Gao, Xiang Meng, Wei Wang  

Org. Lett. 2022, 24:28, 5034-5039 

images_medium_ol2c01768_0006.gif

Synthesis of 𝛼-Aryl Primary Amides from 𝛼-Silyl Nitriles and Aryl Sulfides through [3,3]-Sigmatropic Rearrangement

Fan Luo, Hui Zhou, Xiao-Bei Chen, Xue-Jun Liu, Xiao-Dong Chen, Peng-Fei Qian, Xin-Ping Wu, Wei Wang, Shi-Lei Zhang 

Org. Lett. 2022, 24:8, 1700-1705 

Screen Shot 2022-10-29 at 10.40.36 PM.png

Designing Efficient Cascade Reactions in Drug Discovery 

Chenguang Yu, He Huang, Chunquan Sheng, Wei Wang

Green Chemistry in Drug Discovery. 2022, 213-235

11.webp

Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development 

Ian Henderson, Fanxun Zheng, Nazmul Bhuiyan, Dan Luo, Maria Martinez, Jane Smoake, Fangchao Bi, Chamani Perera, David Johnson, Thomas Prisinzano, Wei Wang, George Uhl

Biochemical pharmacology. 2022, 195, 114868

Screen Shot 2022-10-29 at 11.34.23 PM.png

2021

A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

Junwei Chen, Na Wang, Hongjuan Tong, Chao Song, Huijuan Ma, Yajun Zhang, Feng Gao, Huan Xu, Wei Wang, Kaiyan Lou

Chinese Chemical Letters. 2021, 32:12, 3876-3881

Screen Shot 2022-10-29 at 11.48.45 PM.png

Aminocatalytic stereoselective synthesis of (E)-𝛼-naphthyl enals via cross-coupling reaction of 1-bromo-2-napthols with enals

Xixi Song, Fangchen Song, Xiang Meng, Peng Ji, Wei Wang

Green Synthesis and Catalysis. 2021, 2:4, 377-380

Screen Shot 2022-10-29 at 11.58.04 PM.png

Construction of Enantioenriched γ,γ-Disubstituted Butenolides Enabled by Chiral Amine and Lewis acid Cascade Cocatalysis

Chenguang Yu, Peng Ji, Yueteng Zheng, Xiang Meng, Wei Wang

Org. Lett. 2021, 23:19, 7656-7660

111.gif

Organophotocatalytic dearomatization of insoles, pyrrole and bento (thio) furans via a Giese-type transformation

Yueteng Zhang, Peng Ji, Feng Gao, Yue Dong, He Huang, Changqing Wang, Ziyuan Zhou, Wei Wang

Communications Chemistry. 2021, 4:1, 1-13

Screen Shot 2022-10-30 at 12.28.37 AM.png

Organophotocatalyzed E and Z stereoselective Csp3-Csp2 bond forming cross coupling reactions of carboxylic acids with β-aryl-vinyl halides

He Huang, Yueteng Zheng, Peng Ji, Patrick Mariano, Wei Wang

Green Synthesis and Catalysis. 2021, 2:1, 27-31

Screen Shot 2022-10-30 at 12.39.35 AM.png

Photoredox Asymmetric Nucleophilic Dearomatization of Indoles with Neutral Radicals

Yueteng Zhang, Peng Ji, Feng Gao, He Huang, Fanxun Zeng, Wei Wang

ACS Catal. 2021, 11:2, 998-1007

Screen Shot 2022-10-30 at 12.57.15 AM.png

Facile Synthesis of 2H-Benzo[H]Chromenes via an Arylamine-Catalyzed Mannich Cyclization Cascade Reaction

Yueteng Zhang, Peng Ji, Xiang Meng, Feng Gao, Fanxun Zeng, Wei Wang

Molecules. 2021, 26:12, 3617 

7.jpg

2020

Organophotoredox-Catalyzed Formation of Alkyl-Aryl and- Alkyl C-S/Se Bonds from Coupling of Redox-Active Esters with Thio/Selenosulfonates

Yue Dong, Peng Ji, Yueteng Zhang, Changqing Wang, Xiang Meng, Wei Wang 

Org. Lett. 2020, 22:24, 9562-9567 

6.png

Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

Yue Dong, Renshuai Liu, Wei Wang

Green Synthesis and Catalysis. 2020, 1:2, 83-85 

5.png

An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties

Niloufar Mollasalehi, Liberty Francois-Moutal, David Scott, Judith Tello, Haley Williams, Brendan Mahoney, Jacob Carlson, Yue Dong, Xingli Li, Victor Miranda, Vijay Gokhale, Wei Wang, Sami Barmada, May Khanna

ACS Chem. Biol. 2020, 15:11, 2854-2859 

12.gif

Aldehydes Switch Regioselectivity: a Prins Cyclization Strategy for the Synthesis of Indoline-fused THFs and Indole-fused Oxepanes

Xiaobei Chen, Yuanrui Jiang, Huihui Geng, Xingyu Liu, Yizhuo Huang, Jingwei Lu, Chenjing Gao, Shilei Zhang, Jiang Zhang, Wei Wang

Adv. Synth. Cal. 2020, 362:13, 2620-2625

22.jpeg

Enantioselective [4+2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis

Jing Chen, Yiwei Fu, Yang Yu, Jian-Rong Wang, Yue-Wei Guo, Hao Li, Wei Wang

Org. Lett. 2020, 22:15, 6061-6066

Screen Shot 2022-10-30 at 2.44.52 PM.png

One-pot synthesis of salicylaldehyde containing biaryl frameworks via an aminocatalytic Diels-Alder-retro-Diels-Alder cascade reaction of ynals with 2-pyrones 

Xixi Song, Yueteng Zhang, Peng Ji, Fanxun Zeng, Fangchao Bi, Wei Wang

Green Synthesis and Catalysis. 2020, 1:1, 66-69

222.jpeg

Synthesis of Enantioenriched 𝛼-Deuterated 𝛼-Amino Acids Enabled by an Organophotocatalytic Radical Approach

Peng Ji, Yueteng Zhang, Yue Dong, He Huang, Yongyi Wei, Wei Wang

Org. Lett. 2020, 22:4, 1557-1562

33.gif

Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange Approach

Yueteng Zhang, Peng Ji, Yue Dong, Yongyi Wei, Wei Wang

ACS Cat. 2020, 10:3, 2226-2230

333.gif

Copper Promoted Aerobic Oxidative C(sp3)-C(sp3) Bond Cleavage of N-(2-(Pyridine-2-yl)-ethyl)anilines

Yang Yu, Yong Zhang, Chengdu Sun, Lei Shi, Wei Wang, Hao Li

J. Org. Chem. 2020, 85:4, 2725-2732

3333.gif

Direct, stereoselective thioglycosylation enabled by an organophotoredox radical strategy

Peng Ji, Yueteng Zhang, Feng Gao, Fangchao Bi, Wei Wang

Chem. Sci. 2020, 11:48, 13079-13084

Screen Shot 2022-10-31 at 1.35.29 PM.png

2019

Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis

Huihui Geng, Xiaobei Chen, Jingjing Gui, Yueteng Zhang, Zuyuan Shen, Pengfei Qian, Junwei Chen, Shilei Zhang, Wei Wang

Nature Catalysis. 2019, 2:12, 1071-1077

Screen Shot 2022-10-31 at 12.40.40 PM.png

Visible Light-mediated radical process for the synthesis of C-glycoamino acids

Peng Ji, Yueteng Zhang, Yongyi Wei, He Huang, Wenbo Hu, Wei Wang

Abstracts of Papers of the American Chemical Society 2019, 258

Organocatalytic thioesterification of aldehydes with visible light

Yueteng Zhang, Peng Ji, Wenbo Hu, Yongyi Wei, He Huang, Wei Wang

Abstracts of Papers of the American Chemical Society 2019, 258

Fluorescence imaging of Fe (II) flux in ischemic stroke

Yongyi Wei, Li Wan, Rong Pan, Keniaan Liu, Wei Wang

Abstracts of Papers of the American Chemical Society 2019, 258

Organocatalytic transformation of aldehydes to thioesters with visible light

Yueteng Zhang, Peng Ji, Wenbo Hu, Yongyi Wei, he Huang, Wei Wang

Chem.-Eur. J. 2019, 25:35, 8225-8228

4.jpeg

Synthesis of 3-aminoindan-1-one derivatives from 2-acetylbenzaldehydes and secondary amines by Mannich annulation

Yong Zhang, Yonghai Liu, Shuai Zhang, Lei Shi, Wei Wang, Hao Li

Tetrahedron Lett. 2019, 60:22, 1463-1466

Screen Shot 2022-10-31 at 12.57.17 PM.png

Visible-Light-Mediated, Chemo- and Stereoselective Radical Process for the Synthesis of C-Glycoamino Acids

Peng Ji, Yueteng Zhang, Yongyi Wei, He Huang, Wenbo Hu, Patrick Mariano, Wei Wang

Org.Lett. 2019, 21:9, 3086-3092

44.gif

Construction of N-Alkyl- and N-Arylaziridines from Unprotected Amines via C-H Oxidative Amination Strategy

Yang Yu, Meijuan Li, Yong Zhang, Yonghai Liu, Lei Shi, Wei Wang, Hao Li

Org.Lett. 2019, 21:4, 904-907

5.webp

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

Zuyuan Shen, Shilei Zhang, Huihui Geng, Jiarui Wang, Xinyu Zhang, Anqi Zhou, Cheng Yao, Xiaobei Chen, Wei Wang

Org.Lett. 2019, 21:2, 448-452

55.gif

Photocatalytic C-H simulation of heteroarenes by using trialkylhydrosilanes

Shihui Liu, Peng Pan, Huagiang Fan, Hao Li, Wei Wang, Yongquiang Zhang

Chem. Sci. 2019, 10:13, 3817-3825

Screen Shot 2022-10-31 at 1.30.39 PM.png

Other Publications

Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells

Xiaolei Wang, Kaiyan Lou, Xiaodong Song, Huijuan Ma, Xinyi Zhou, Huan Xu, Wei Wang 

Toxicology and Applied Pharmacology. 2020, 396, 115001

Screen Shot 2022-10-31 at 11.33.09 AM.png

Investigation of the Relationship Between H2O2 and HClO in Living Cells by a Bifunctional, Dual-ratiometric Responsive Fluorescent Probe

Jinliang Han, Xinjiang Liu, Haiqing Xiong, Jingpei Wang, Benhau Wang, Xiangzhi Song, Wei Wang

Anal Chem. 2020, 92:7, 5134-5142

3.gif

Investigation of the Relationship Between H2O2 and HClO in Living Cells by a Bifunctional, Dual-ratiometric Responsive Fluorescent Probe

Jinliang Han, Xinjiang Liu, Haiqing Xiong, Jingpei Wang, Benhau Wang, Xiangzhi Song, Wei Wang

Anal Chem. 2020, 92:7, 5134-5142

3.gif

Orlistat increase arsenate tolerance in THP-1 derived macrophages through the up-regulation of ABCA1

Kaiyan Lou, Ping Huang, Huijuan Ma, Xiaolei Wang, Huan Xu, Wei Wang 

Drug and Chemical Toxicology. 2022, 45:1, 274-282

Screen Shot 2022-10-29 at 11.00.46 PM.png

An anthracenecarboximide-guanidine fluorescent probe selective detection of glyoxals under weak acidic conditions

Junwei Chen, Yuna Lin, Wanjin Xing, Xingchen Zhang, Huan Xu, Wei Wang, Kaiyan Lou

RSC Adv. 2022, 12:15, 9473-9477

Screen Shot 2022-10-29 at 11.07.24 PM.png

A PET-based fluorescent probe for monitoring labile Fe (ii) pools in macrophage activations and ferroptosis

Wanjin Xing, Hang Xu, Huijuan Ma, Syed Ali Abbas Abedi, Shanshan Wang, Xingchen Zhang, Xiaogang Liu, Huan Xu, Wei Wang, Kaiyan Lou

Chem. Commun. 2022, 58:18, 2979-2982

Screen Shot 2022-10-29 at 11.17.00 PM.png

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Shipeng He, Junhui Ma, Yuxin Fang, Ying Liu, Shanchao Wu, Guoqiang Dong, Wei Wang, Chunquan Sheng

Acta Pharmaceutica Sinica B. 2021, 11:6, 1617-1628

Screen Shot 2022-10-30 at 12.14.41 AM.png

Myricetin protects natural killer cells from arsenide induced DNA damage by attenuating oxidative stress and retaining poly (ADP-ribose) polymerase 1 activity

Huijuan Ma, Xiaodong Song, Ping Huang, Weiwei Zhang, Xinyue Ling, Liaoning Yang, Wenwei Wu, Huan Xu, Wei Wang

Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2021, 865, 503337

Screen Shot 2022-10-30 at 12.22.03 AM.png

Compositions and methods for controlling cellular function

Fu-sen Liang, Wei Wang

US10907219, 2021

Screen Shot 2022-10-30 at 12.32.28 AM.png

Synthesis of β-Silyl 𝛼-Amino Acids via Visible-Light-Mediated Hydrosilylation 

Yi Wan, Jiajie Zhu, Qiyang Yuan, Wei Wang, Yongqiang Zhang

Org. Lett. 2021, 23:4, 1406-1410

1111.gif

PIFA-Mediated Cross-Dehydrogenative Coupling of N-Heteroarenes with Cyclic Ether: Ethanol as an Efficient Promoter

Xiang Li, Chaoyang Liu, Shixun Guo, Wei Wang, Yongqiang Zhang

Eur. J. Org. Chem. 2021, 3, 411-421

Screen Shot 2022-10-30 at 12.52.57 AM.png

An "AND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

Wenli Wang, Junwei Chen, Huijuan Ma, Wanjin Xing, Nan Lv, Banning Zhang, Huan Xu, Wei Wang, Kaiyan Lou

Chemical Communications. 2021, 57:66, 8166-8169

11111.jpeg

Autophagy: New Insights into Its Roles in Cancer Progression and Drug Resistance 

Steffan Nawrocki, Wei Wang, Jennifer Carew

Cancers. 2020, 12:10, 3005 

Fluorophore-Promoted Facile Deprotonation and Exocyclic Five-Membered Ring Cyclization for Selective and Dynamic Tracking of Labile Glyoxals

Huan Xu, Qianqian Liu, Xiaodong Song, Chao Wang, Xinru Wang, Shengnan Ma, Xiaolei Wang, Yan Feng, Xiangming Meng, Xiaogang Liu, Wei Wang, Kaiyan Lou

Anal. Chem. 2020, 92:20, 13829-13828 

122.gif

Graphitic Carbon Nitride Polymer as a Recyclable Photoredox Catalyst for Decarboxylative Alkynylation of Carboxylic Acids

Jiaqi Guo, Yating Wang, Yuhang Li, Kailin Lu, Shihui Liu, Wei Wang, Yongqiang Zhang

Adv. Synth. Cal. 2020, 362:18, 3898-3904 

Screen Shot 2022-10-30 at 2.35.42 PM.png

ENANTIOSELECTIVE [4+2] CYCLOADDITION REACTION OF VINYLQUINOLINES WITH DIENALS ENABLED BY SYNERGISTIC ORGANOCATALYSIS

Jing Chen, Yiwei Fu, Yang Yu, Jian-Rong Wang, Yue-Wei Guo, Hao Li, Wei Wang

Org. Lett. 2020, 22, 6061-6066 

4.png

Methylglyoxal produced by tumor cells through formaldehyde-enhanced Warburg effect potentiated polarization of tumor-associated macrophages

Huijuan Ma, Zhaoqian Ding, ying Xie, Linyi Li, Dan Li, Kaiyan Lou, Wei Wang, Huan Xu 

Toxicology and Applied Pharmacology 2022, 438, 115910

Screen Shot 2022-10-28 at 10.51.28 AM.png

Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis

Huijuan Ma, Jinxuan Lin, Linyi Li, Zhaoquian ding, Ping Huang, Xiaodong Song, Kaiyan Lou, Wei Wang, Huan Xu

Chemosphere. 2021, 282, 131149

Screen Shot 2022-10-30 at 12.04.19 AM.png

2019

ORGANOCATALYTIC TRANSFORMATION OF ALDEHYDES TO THIOESTERS WITH VISIBLE LIGHT

Yueteng Zhang, Peng Ji, Wenbo Hu, Yongyi Wei, He Huang, and Wei Wang*

Chem. Eur. J. 2019, 25

aldehyde.png

VISIBLE-LIGHT-MEDIATED, CHEMO- AND STEREOSELECTIVE RADICAL PROCESS FOR THE SYNTHESIS OF C-GLYCOAMINO ACIDS

Peng Ji, Yueteng Zhang, Yongyi Wei, He Huang, Wenbo Hu, Patrick A. Mariano,* and Wei Wang*

Org. Lett., 2019, 21, 3086.

glycopeptide.png

CONSTRUCTION OF N-ALKYL- AND N-ARYLAZIRIDINES FROM UNPROTECTED AMINES VIA C–H OXIDATIVE AMINATION STRATEGY

Yang Yu, Meijuan Li, Yong Zhang, Yonghai Liu, Lei Shi, Wei Wang*, and Hao Li*

Org. Lett., 2019, 21, 904–907

silicao.png

TRIDEUTEROMETHYLATION ENABLED BY A SULFOXONIUM METATHESIS REACTION

Zuyuan Shen, Shilei Zhang, Huihui Geng, Jiarui Wang†, Xinyu Zhang, Anqi Zhou, Cheng Yao, Xiaobei Chen*, and Wei Wang*

Org. Lett., 2019, 21, 448–452

silicao.png

PHOTOCATALYTIC C–H SILYLATION OF HETEROARENES BY USING TRIALKYLHYDROSILANES

Shihui Liu, Peng Pan, Huaqiang Fan, Hao Li, Wei Wang*, Yongqiang Zhang*

Chem. Sci., 2019,10, 3817-3825

silicao.png

PRACTICAL SYNTHESIS OF C1 DEUTERATED ALDEHYDES ENABLED BY NHC CATALYSIS

Huihui Geng, Xiaobei Chen, Jingjing Gui, 

Yueteng Zhang, Zuyuan Shen, Pengfei Qian, Junwei Chen, Shilei Zhang, Wei Wang 

Nature Catalysis, 2019

123456.png

PRACTICAL SYNTHESIS OF C1 DEUTERATED ALDEHYDES ENABLED BY NHC CATALYSIS

Huihui Geng, Xiaobei Chen, Jingjing Gui, 

Yueteng Zhang, Zuyuan Shen, Pengfei Qian, Junwei Chen, Shilei Zhang, Wei Wang 

Nature Catalysis, 2019

123456.png

PRACTICAL SYNTHESIS OF C1 DEUTERATED ALDEHYDES ENABLED BY NHC CATALYSIS

Huihui Geng, Xiaobei Chen, Jingjing Gui, 

Yueteng Zhang, Zuyuan Shen, Pengfei Qian, Junwei Chen, Shilei Zhang, Wei Wang 

Nature Catalysis, 2019

123456.png

PRACTICAL SYNTHESIS OF C1 DEUTERATED ALDEHYDES ENABLED BY NHC CATALYSIS

Huihui Geng, Xiaobei Chen, Jingjing Gui, 

Yueteng Zhang, Zuyuan Shen, Pengfei Qian, Junwei Chen, Shilei Zhang, Wei Wang 

Nature Catalysis, 2019

123456.png

2018

SYNTHESIS OF 2-QUINOLINONES VIA A HYPERVALENT IODINE(III)-MEDIATED INTRAMOLECULAR DECARBOXYLATIVE HECK-TYPE REACTION AT ROOM TEMPERATURE

Huaqiang Fan, Peng Pan, Yongqiang Zhang*, and Wei Wang*

Org. Lett., 2018, 20, 7929

Read More
ol-2018-03503s_0006.gif

ANALYTE REGENERATION FLUORESCENT PROBES FOR FORMALDEHYDE ENABLED BY REGIOSPECIFIC FORMALDEHYDE-INDUCED INTRAMOLECULARITY

Hang Xu, Huan Xu, Shengnan Ma, Xiani Chen, Lixian Huang, Junwei Chen, Feng Gao, Rui Wang, Kaiyan Lou*, and Wei Wang*

J. Am. Chem. Soc., 2018, 140, 16408.

1234.jpg

DISCOVERY OF NOVEL INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) AND HISTONE DEACETYLASE (HDAC) DUAL INHIBITORS

Kun Fang, Guoqiang Dong, Yu Li, Shipeng He, Ying Wu, Shanchao Wu, Wei Wang*, and Chunquan Sheng*

ACS Med. Chem. Lett., 2018, 9, 312

111.png

DIRECT ACCESS OF THE CHIRAL QUINOLINYL CORE OF CINCHONA ALKALOIDS VIA A BRØNSTED ACID AND CHIRAL AMINE CO-CATALYZED CHEMO- AND ENANTIOSELECTIVE ALPHA-ALKYLATION OF QUINOLINYLMETHANOLS WITH ENALS

Mengchao Tong, Sinan Wang, Jinchen Zhuang, Cong Qin, Hao Li*, and Wei Wang*

Org. Lett., 2018, 20, 1195

111.png

ALPHA-FUNCTIONALIZATION OF 2-VINYLPYRIDINES VIA A CHIRAL PHOSPHINE CATALYZED ENANTIOSELECTIVE CROSS RAUHUT–CURRIER REACTION

Cong Qin, Yonghai Liu, Yang Yu, Yiwei Fu, Hao Li*, and Wei Wang*

Org. Lett., 2018, 20, 1304

Untitled.png

PD-CATALYZED DEBENZYLATION AND DEALLYLATION OF ETHERS AND ESTERS WITH SODIUM HYDRIDE

Yujian Mao, Ye Liu, Yanwei Hu, Liang Wang, Shilei Zhang*, and Wei Wang*

ACS Catal., 2018, 8, 3016

Untitled.png

IMPROVING THE POTENCY OF CANCER IMMUNOTHERAPY BY DUAL TARGETING OF IDO1 AND DNA

ChemMedChem 2018, 13, 30

K. Fang, G. Dong, H. Wang, S. He, S. Wu, W. Wang, C. Sheng,

Untitled.png

2017

SYNTHESIS OF Z-ALKENES VIA VISIBLE LIGHT PROMOTED PHOTOCATALYTIC E → ZISOMERIZATION UNDER METAL-FREE CONDITIONS

Chem. Commun., 2017,53, 12918

Wenbin Cai, Huaqiang Fan, Dazhong Ding, Yongqiang Zhang, Wei Wang

Untitled.png

CO(OAC)2-CATALYZED TRIFLUOROMETHYLATION AND C(3)-SELECTIVE ARYLATION OF 2-(PROPARGYLAMINO)PYRIDINES VIA A 6-ENDO-DIG CYCLIZATION

Org. Lett., 2017, 19, 6052

Jianjun Li, Yifan Lei, Yang Yu, Cong Qin, Yiwei Fu, Hao Li, Wei Wang

Untitled.png

AN UNCONVENTIONAL REDOX CROSS CLAISEN CONDENSATION–AROMATIZATION OF 4-HYDROXYPROLINES WITH KETONES

J. Org. Chem., 2017, 82, 8419

Mi Tang, Rengwei Sun, Hao Li, Xinhong Yu, Wei Wang

Read More
Untitled.png

CHEMO- AND REGIOSELECTIVE ORGANO-PHOTOREDOX CATALYZED HYDROFORMYLATION OF STYRENES VIA A RADICAL PATHWAY

J. Am. Chem. Soc., 2017, 139,  9799

He Huang, Chenguang Yu, Yueteng Zhang, Yongqiang Zhang, Patrick S Mariano, Wei Wang

Untitled.png

SYNTHESIS OF ALDEHYDES BY ORGANOCATALYTIC FORMYLATION REACTIONS OF BORONIC ACIDS WITH GLYOXYLIC ACID

Angew. Chem. Int. Ed. 2017, 56, 8201

He Huang, Chenguang Yu, Xiangmin Li, Yongqiang Zhang, Yueteng Zhang, Xiaobei Chen, Patrick S Mariano, Hexin Xie, Wei Wang

Untitled.png

LEWIS ACID-CATALYZED C(SP3)–C(SP3) BOND FORMING CYCLIZATION REACTIONS FOR THE SYNTHESIS OF TETRAHYDROPROTOBERBERINE DERIVATIVES

Adv. Synth. Catal. 2017, 359, 2191

Jianjun Li, Cong Qin, Yang Yu, Huaqiang Fan, Yiwei Fu, Hao Li, Wei Wang

Untitled.png

IRON-CATALYZED ANTI-MARKOVNIKOV HYDROAMINATION OF VINYLPYRIDINES

Asian J. Org. Chem. 2017, 6, 694

Yahui Peng, Cong Qin, Xiaobei Chen, Jianjun Li, Hao Li, Wei Wang

Untitled.png

SYNTHESIS OF INDOLIZINES VIA REACTION OF 2-SUBSTITUED AZAARENES WITH ENALS BY AN AMINE-NHC RELAY CATALYSIS

Org. Lett. 2017, 19, 2010

Hongxian Li, Xiangmin Li, Yang Yu, Jianjun Li, Yuan Liu, Hao Li, Wei Wang

Untitled.png

ENGINEERING IRON RESPONSES IN MAMMALIAN CELLS BY SIGNAL-INDUCED PROTEIN PROXIMITY

ACS Synth. Biol., 2017, 6, 921

Guihua Zeng, Huanqiu Li, Yongyi Wei, Weimin Xuan, Roushu Zhang, Larisa E Breden, Wei Wang, Fu-Sen Liang

Untitled.png

PALLADIUM-CATALYZED DIVERGENT REGIOSELECTIVE HOMOCOUPLING AND HYDROXYLATION OF 3-ARYLBENZO[D]ISOXAZOLES

Adv. Synth. Catal. 2017, 359, 410

Ying Guo, Kun‐Kun Yu, Li‐Hao Xing, Hong‐Wei Liu, Wei Wang, Ya‐Fei Ji

Untitled.png

VISIBLE-LIGHT-PROMOTED NICKEL- AND ORGANIC-DYE-COCATALYZED FORMYLATION REACTION OF ARYL HALIDES AND TRIFLATES AND VINYL BROMIDES WITH DIETHOXYACETIC ACID AS A FORMYL EQUIVALENT

Angew. Chem. Int. Ed. 2017, 56, 1500

He Huang, Xiangmin Li, Chenguang Yu, Yueteng Zhang, Patrick S Mariano, Wei Wang

Untitled.png

DISCOVERY OF IDO1 AND DNA DUAL TARGETING ANTITUMOR AGENTS

Org. Biomol. Chem., 2017,15, 9992

Kun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng

Untitled.png

A DYNAMIC KINETIC ASYMMETRIC TRANSFER HYDROGENATION–CYCLIZATION TANDEM REACTION: AN EASY ACCESS TO CHIRAL 3,4-DIHYDRO-2H-PYRAN-CARBONITRILES

Chem. Commun., 2017, 53, 6113

Dongsong Zheng, Qiankun Zhao, Xiaoying Hu, Tanyu Cheng, Guohua Liu, Wei Wang

Untitled.png

DIRECT CΑ-HETEROARYLATION OF STRUCTURALLY DIVERSE ETHERS VIA A MILD N-HYDROXYSUCCINIMIDE MEDIATED CROSS-DEHYDROGENATIVE COUPLING REACTION

Chem. Sci., 2017,8, 4044

Shihui Liu, Aoxia Liu, Yongqiang Zhang, Wei Wang

Untitled.png

ORCHESTRATION OF DUAL CYCLIZATION PROCESSES AND DUAL QUENCHING MECHANISMS FOR ENHANCED SELECTIVITY AND DRASTIC FLUORESCENCE TURN-ON DETECTION OF CYSTEINE

Chem. Commun., 2017,53, 3583

Hongjuan Tong, Jianhong Zhao, Xiangmin Li, Yajun Zhang, Shengnan Ma, Kaiyan Lou, Wei Wang

Untitled.png

2016

ENZYMATIC CLEAVAGE AND SUBSEQUENT FACILE INTRAMOLECULAR TRANSCYCLIZATION FOR IN SITU FLUORESCENCE DETECTION OF Γ-GLUTAMYLTRANSPETIDASE ACTIVITIES

Anal. Chem., 2016, 88, 10816

Hongjuan Tong, Yongjun Zheng, Li Zhou, Xiangmin Li, Rui Qian, Rui Wang, Jianhong Zhao, Kaiyan Lou, Wei Wang

1.png
1.png

HIGHLY REGIO- AND STEREOSELECTIVE SYNTHESIS OF Z AND E ENOL ESTERS BY AN AMINE-CATALYZED CONJUGATE ADDITION–REARRANGEMENT REACTION OF YNALS WITH CARBOXYLIC ACIDS

ACS Catal., 2016, 6, 8030

He Huang, Xinshuai Zhang, Chenguang Yu, Xiangmin Li, Yueteng Zhang, Wei Wang

1.png
1.png

A MULTIFACETED DIRECTING GROUP SWITCHING YNONES AS MICHAEL DONORS IN CHEMO-, ENANTIO-, AND Γ-SELECTIVE 1,4-CONJUGATE ADDITIONS WITH NITROOLEFINS

J. Org. Chem., 2016, 81, 8296

Weiwei Liu, Liwei Zou, Binbin Fu, Xinran Wang, Ke Wang, Zhongwen Sun, Fangzhi Peng, Wei Wang, Zhihui Shao

1.png

RATIONAL DESIGN OF AN ULTRASENSITIVE AND HIGHLY SELECTIVE CHEMODOSIMETER BY A DUAL QUENCHING MECHANISM FOR CYSTEINE BASED ON A FACILE MICHAEL-TRANSCYCLIZATION CASCADE REACTION

Chem. Eur. J.2016, 22, 9247.

Xiangmin Li, Yongjun Zheng, Hongjuan Tong, Rui Qian, Lin Zhou, Guixia Liu, Yun Tang, Hao Li, Kaiyan Lou, Wei Wang

1.png

ANILINE-PROMOTED CYCLIZATION–REPLACEMENT CASCADE REACTIONS OF 2-HYDROXYCINNAMALDEHYDES WITH VARIOUS CARBONIC NUCLEOPHILES THROUGH IN SITU FORMED N,O-ACETALS

Chem. Eur. J. 2016, 22, 9240

Chenguang Yu, He Huang, Xiangmin Li, Yueteng Zhang, Hao Li, Wei Wang

1.png

A MILD AND SELECTIVE PROTECTING AND REVERSED MODIFICATION OF THIOLS

Tetrahedron Lett. 2016, 57, 2600

Xiangmin Li, Hongxian Li, Wei Yang, Jinchen Zhuang, Hao Li, Wei Wang

1.png

A DONOR–ACCEPTOR TRIPTYCENE–COUMARIN HYBRID DYE FEATURING A CHARGE SEPARATED EXCITED STATE AND AIE PROPERTIES

Org. Biomol. Chem., 2016, 14, 5007-

Rui Qian, Hongjuan Tong, Cui Huang, Junhao Li, Yun Tang, Rui Wang, Kaiyan Lou, Wei Wang

1.png
1.png

FACILE INSTALLATION OF 2-REVERSE PRENYL FUNCTIONALITY INTO INDOLES BY A TANDEM N-ALKYLATION–AZA-COPE REARRANGEMENT REACTION AND ITS APPLICATION IN SYNTHESIS

Chem. Eur. J., 2016, 22, 716

Xiaobei Chen, Huaqiang Fan, Shilei Zhang, Chenguang Yu, Wei Wang

1.png

SYNERGISTIC CHIRAL IMINIUM AND PALLADIUM CATALYSIS: HIGHLY REGIO- AND ENANTIOSELECTIVE [3 + 2] ANNULATION REACTION OF 2-VINYLCYCLOPROPANES WITH ENALS

Beilstein J. Org. Chem., 2016, 12, 1340

Haipan Zhu, Peile Du, Jianjun Li, Ziyang Liao, Guohua Liu, Hao Li, Wei Wang

1.png

FACILE CONSTRUCTION OF PYRROLO[1,2-B]ISOQUINOLIN-10(5H)-ONES VIA A REDOX-AMINATION–AROMATIZATION–FRIEDEL–CRAFTS ACYLATION CASCADE REACTION AND DISCOVERY OF NOVEL TOPOISOMERASE INHIBITORS

Chem. Commun., 2016, 52, 9593

Shanchao Wu, Na Liu, Guoqiang Dong, Lin Ma, Shengzheng Wang, Wencai Shi, Kun Fang, Shuqiang Chen, Jian Li, Wannian Zhang, Chunquan Sheng, Wei Wang

1.png

ORGANOCATALYTIC ASYMMETRIC ADDITION OF ALCOHOLS TO CYCLIC TRIFLUOROMETHYL KETIMINES: HIGHLY ENANTIOSELECTIVE SYNTHESIS OF CHIRAL N,O-KETALS

Org. Biomol. Chem., 2016, 14, 6193

Ding Zhou, Xueting Yu, Jian Zhang, Wei Wang, Hexin Xie

1.png

STEREOSELECTIVE ORGANOCATALYTIC OXIDATION OF ALCOHOLS TO ENALS: A HOMOLOGATION METHOD TO PREPARE POLYENES

Chem. Commun., 2016, 52, 3532

Xiaobei Chen, Yinan Zhang, Huixin Wan, Wei Wang, Shilei Zhang

1.png
1.png

ENANTIOSELECTIVE ORGANOCATALYTIC MICHAEL ADDITION OF ISORHODANINES TO Α,Β-UNSATURATED ALDEHYDES

Org. Biomol. Chem., 2016, 14, 3926-3933

Shanchao Wu, Yu Li, Yongqiang Zhang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Wei Wang, Wannian Zhang, Chunquan Sheng

1.png
1.png

2015

STATE-OF-THE-ART STRATEGIES FOR TARGETING PROTEIN–PROTEIN INTERACTIONS BY SMALL-MOLECULE INHIBITORS

Chem. Soc. Rev., 2015,44, 8238

Chunquan Sheng, Guoqiang Dong, Zhenyuan Miao, Wannian Zhang  and  Wei Wang

3.png

A QUININE-SQUARAMIDE CATALYZED ENANTIOSELECTIVE AZA-FRIEDEL–CRAFTS REACTION OF CYCLIC TRIFLUOROMETHYL KETIMINES WITH NAPHTHOLS AND ELECTRON-RICH PHENOLS

Org. Lett., 2015, 17, 5554

Ding Zhou, Zheng Huang, Xueting Yu, Youxin Wang, Jian Li, Wei Wang*, and Hexin Xie*

8.png

ORGANOCATALYTIC AEROBIC OXIDATION OF BENZYLIC SP3 C–H BONDS OF ETHERS AND ALKYLARENES PROMOTED BY A RECYCLABLE TEMPO CATALYST

Org. Lett., 2015, 17, 5492

Zhiguang Zhang, Yuan Gao, Yuan Liu, Jianjun Li, Hexin Xie, Hao Li*, and Wei Wang

9.png

ASYMMETRIC SYNTHESIS OF SYN-PROPARGYLAMINES AND UNSATURATED Β-AMINO ACIDS UNDER BRØNSTED BASE CATALYSIS

Nature communications, 2015, 6, 8544

Yingcheng Wang, Mingjie Mo, Kongxi Zhu, Chao Zheng, Hongbin Zhang, Wei Wang & Zhihui Shao

10.png

NEW SMALL-MOLECULE DRUG DESIGN STRATEGIES FOR FIGHTING RESISTANT INFLUENZA A

Acta Pharmaceutica Sinica B 2015, 5, 419

Zuyuan Shena, Kaiyan Loua, Wei Wang

11.png
12.png

REACTION-BASED “OFF–ON” FLUORESCENT PROBE ENABLING DETECTION OF ENDOGENOUS LABILE FE2+ AND IMAGING OF ZN2+-INDUCED FE2+ FLUX IN LIVING CELLS AND ELEVATED FE2+ IN ISCHEMIC STROKE

Bioconjugate Chem., 2016, 27, 302

Weimin Xuan, Rong Pan, Yongyi Wei, Yanting Cao, Huanqiu Li, Fu-Sen Liang, Ke-Jian Liu*, and Wei Wang*

13.png

DIVERGENT SYNTHESIS OF IMIDAZOLES AND QUINAZOLINES VIA PD(OAC)2-CATALYZED ANNULATION OF N-ALLYLAMIDINES

Org. Lett., 2015, 17, 3434

L Xu, H Li, Z Liao, K Lou, H Xie, H Li, W Wang

14.png

FECL3-CATALYZED SELECTIVE ACYLATION OF AMINES WITH 1,3-DIKETONES VIA C–C BOND CLEAVAGE

Tetrahedron Letters, 2015, 56, 3093–3096

S Wang, Y Yu, X Chen, H Zhu, P Du, G Liu, L Lou, H Li, W Wang

15.png
16.png

CONSTRUCTING DE NOVO H2O2 SIGNALING VIA INDUCED PROTEIN PROXIMITY

ACS Chem. Biol., 2015, 10, 1404

G Zeng, R Zhang, W Xuan, W Wang, FS Liang

17.png

DIVERGENT CASCADE CONSTRUCTION OF SKELETALLY DIVERSE “PRIVILEGED” PYRAZOLE-
DERIVED MOLECULAR ARCHITECTURES

European Journal of Organic Chemistry 2015, 9, 2030

Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang, Chunquan Sheng, Wei Wang

18.png

AN EFFICIENT METHOD FOR THE PRODUCTION OF TERMINAL ALKYNES
FROM 1,1-DIBROMO-1-ALKENES AND ITS APPLICATION IN THE TOTAL SYN-
THESIS OF NATURAL PRODUCT DIHYDROXERULIN

Adv. Synth. Catal. 2015, 357, 553

S Liu, X Chen, Y Hu, L Yuan, S Chen, P Wu, W Wang, S Zhang, W Zhang

19.png

ORGANOCATALYTIC ENANTIOSELECTIVE DIRECT ADDITIONS OF ALDEHYDES TO 4-VINYLPYRIDINES AND ELECTRON-DEFICIENT VINYLARENES AND THEIR SYNTHETIC APPLICATIONS

J. Am. Chem. Soc. 2015, 137, 2303

S Wang, X Li, H Liu, L Xu, J Zhuang, J Li, H Li, W Wang

20.png

FRET DETECTION OF LYMPHOCYTE FUNCTION– ASSOCIATED ANTIGEN-1 CONFORMATIONAL EXTENSION

Mol. Biol. Cell, 2015, 26, 43

Alexandre Chigaev, Yelena Smagley, Mark K Haynes, Oleg Ursu, Cristian G Bologa, Liliana Halip, Tudor Oprea, Anna Waller, Mark B Carter, Yinan Zhang, Wei Wang, Tione Buranda, Larry A Sklar

21.png

ORGANOCATALYTIC ENANTIOSELECTIVE MICHAEL ADDITION OF CYCLIC HEMIACETALS TO NITROOLEFINS: A FACILE ACCESS TO CHIRAL SUBSTITUTED 5-AND 6-MEMBERED CYCLIC ETHERS

Org. Biomol. Chem., 2015, 13, 4769

Yadong Zhu, Pengfei Qian, Jiyang Yang, Shaohua Chen, Yanwei Hu, Ping Wu, Wei Wang, Wei Zhang, Shilei Zhang

22.png

NEAR-INFRARED FLUORESCENT PROBES FOR IMAGING OF AMYLOID PLAQUES IN ALZHEIMER׳S DISEASE

Acta Pharmaceutica Sinica B 2015, 5, 25

H Tong, K Lou, W Wang

22.png
22.png

FLUORESCENT THERANOSTIC AGENTS FOR HG2+ DETECTION AND DETOXIFICATION TREATMENT

Chem. Commun., 2015, 51, 4443

C Song, W Yang, N Zhou, R Qian, Y Zhang, K Lou, R Wang, W Wang

22.png

PHOTO-TRIGGERED FLUORESCENT THERANOSTIC PRODRUGS AS DNA ALKYLATING AGENTS FOR MECHLORETHAMINE RELEASE AND SPATIOTEMPORAL MONITORING

Org. Biomol. Chem., 2015, 13, 6742

Y Cao, R Pan, W Xuan, Y Wei, K Liu, J Zhou, W Wang

22.png

2014

ENANTIOSELECTIVE CONSTRUCTION OF FUNCTIONALIZED CYCLOPENTANES BY A RELAY RING-CLOSING METATHESIS AND CHIRAL AMINE (THIO) UREA-PROMOTED MICHAEL ADDITION

Synthesis, 2014, 46, 2601

Yinan Zhang, Xixi Song, Xiaobei Chen, Aiguo Song, Shilei Zhang, Wei Wang

Read More
1.png

HOLLOW ZEOLITIC IMIDAZOLATE FRAMEWORK NANOSPHERES AS HIGHLY EFFICIENT COOPERATIVE CATALYSTS FOR [3+3] CYCLOADDITION REACTIONS

J. Am. Chem. Soc. 2014, 136, 13963

Fang Zhang, Yongyi Wei, Xiaotao Wu, Huangyong Jiang, Wei Wang, and Hexing Li

Read More
2.png

SYNTHESIS OF GAMA-OXO-ALPHA,BETA-DEHYDRO-ALPHA-BUTYLOXYCARBONYL-ALPHA-IMINO ESTERS AND CARBONYLMETHYL 2-PYRIDINYLSULFONES VIA AN MANNICH-ELIMINATION CASCADE

Asian Journal of Organic Chemistry. 2014, 3, 766

Deyan Wu, Jin Zhu, Chunquan Sheng, Wei Wang

Read More
5.png

CATALYTIC ASYMMETRIC ALPHA-HYDROXYAMINATION OF CARBONYLS WITH N-HYDROXYCARBAMATES BECOMES GREENER

ChemCatChem, 2014, 6, 1863

Chenguang Yu, Aiguo Song, Fang Zhang, Wei Wang

Read More
5.png

PAPER FEATURED IN TOP SCIENCE PUBLICATION

Angew. Chem. Int. Ed., 2014, 53, 4940

Aiguo Song, Xishuai Zhang, Xixi Song, Xiaobei Chen, Chenguang Yu, He Huang, Hao Li, Wei Wang

Read More
5.png

ORGANOCATALYTIC ENANTIOSELECTIVE FRIEDEL–CRAFTS REACTION OF 1-NAPHTHOLS WITH ISATINS AND AN UNEXPECTED SPONTANEOUS DEHYDRATION PROCESS

Asian Journal of Organic Chemistry, 2014, 3, 480

Deyan Wu, Xuwen Zhang, Yong Xu, Yingfei Xue, Jian Li, Wei Wang, Jin Zhu

Read More
5.png

FACILE ASSEMBLY OF CHIRAL TETRAHYDROTHIOPYRANS CONTAINING FOUR CONSECUTIVE STEREOCENTERS VIA AN ORGANOCATALYTIC ENANTIOSELECTIVE MICHAEL–MICHAEL CASCADE

Org. Lett., 2014, 16, 692

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, Shanchao Wu, Kun Fang, Zhengang Li, Zhenyuan Miao, Jianzhong Yao, Hao Li, Jian Li, Wannian Zhang, Wei Wang, Chunquan Sheng

Read More
5.png

PEGYLATED NICKEL CARBIDE NANOCRYSTALS AS EFFICIENT NEAR-INFRARED LASER INDUCED PHOTOTHERMAL THERAPY FOR TREATMENT OF CANCER CELLS IN VIVO

Nanoscale, 2014, 6, 12591

Zhiguo Zhou,  Jun Wang, Wei Liu, Chao Yu, Bin Kong, Yanan Sun, Hong Yang, Shiping Yang, Wei Wang

Read More
5.png

HIGHLY ACTIVE, DURABLE AND RECYCLABLE ORDERED MESOPOROUS MAGNETIC ORGANOMETALLIC CATALYSTS FOR PROMOTING ORGANIC REACTIONS IN WATER

J. Mater. Chem. A, 2014, 2, 484

Fang Zhang, Mingzhen Chen, Xiaotao Wu, Wei Wang, Hexing Li

Read More
5.png

BEFORE 2014

NEXT PAGE

see read more

Petri Dish
bottom of page